原发性骨髓化生的放射性同位素研究。
Radio-isotope investigations in primary myeloid metaplasia.
作者信息
BOWDLER A J
出版信息
J Clin Pathol. 1961 Nov;14(6):595-602. doi: 10.1136/jcp.14.6.595.
Abstract
Chromium-51 and iron-59 studies in patients with primary myeloid metaplasia show that the anaemia of the condition is dependent on depression of marrow activity, aggravated in about one-third of cases by accelerated red cell destruction to which the marrow compensatory response is inadequate. Surface measurements of isotope activity assist in assessing dependence on extramedullary sites for erythropoiesis and in diagnosis. The relevance of these findings to the hypotheses of the pathogenesis of the condition is discussed.
摘要
对原发性骨髓化生患者进行的铬-51和铁-59研究表明，该病症的贫血取决于骨髓活性降低，约三分之一的病例中，红细胞加速破坏使贫血加重，而骨髓的代偿反应不足。同位素活性的表面测量有助于评估对髓外造血部位的依赖性及进行诊断。本文讨论了这些发现与该病症发病机制假说的相关性。
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