Mokhtar N, Rousseau-Migneron S, Tancrède G, Nadeau A
Diabetes Research Unit, CHUL Research Center, Laval University Medical Center, Ste-Foy, Quebec, Canada.
Metabolism. 1992 Sep;41(9):1004-8. doi: 10.1016/0026-0495(92)90128-w.
The effect of physical training on total creatine kinase (CK), CK-MM, and CK-MB isoenzyme activity was studied in hearts of diabetic and control rats. Diabetes was induced with streptozotocin (50 mg/kg), and only rats with blood glucose levels between 14 and 22 mmol/L 1 week later were kept in the protocol. Exercise training was performed on a treadmill in a progressive 10-week program. Physical training did not induce any significant changes in plasma glucose or insulin levels in diabetic rats. Total CK, CK-MM, and CK-MB activity was decreased in diabetic rat heart by 27%, 22%, and 56%, respectively. Physical training did not induce any important changes in CK activity in heart of nondiabetic rats. However, in diabetic rat heart, training increased total CK activity by 13%, CK-MM activity by 12%, and CK-MB activity by 31%. We conclude that the decrease in cardiac CK activity observed in chronic experimental diabetes mellitus can be partly alleviated by a program of physical training. This may be one of the mechanisms whereby physical conditioning improves cardiac function in experimental diabetes.
研究了体育锻炼对糖尿病大鼠和对照大鼠心脏中总肌酸激酶（CK）、CK-MM和CK-MB同工酶活性的影响。用链脲佐菌素（50mg/kg）诱导糖尿病，仅将1周后血糖水平在14至22mmol/L之间的大鼠纳入实验方案。在跑步机上进行为期10周的渐进式运动训练。体育锻炼未引起糖尿病大鼠血浆葡萄糖或胰岛素水平的任何显著变化。糖尿病大鼠心脏中的总CK、CK-MM和CK-MB活性分别降低了27%、22%和56%。体育锻炼未引起非糖尿病大鼠心脏中CK活性的任何重要变化。然而，在糖尿病大鼠心脏中，训练使总CK活性增加了13%，CK-MM活性增加了12%，CK-MB活性增加了31%。我们得出结论，慢性实验性糖尿病中观察到的心脏CK活性降低可通过体育锻炼方案得到部分缓解。这可能是体育锻炼改善实验性糖尿病心脏功能的机制之一。
