铝诱导的大鼠急性胆碱能神经毒性

Aluminum-induced acute cholinergic neurotoxicity in rat.

作者信息

Peng J H, Xu Z C, Xu Z X, Parker J C, Friedlander E R, Tang J P, Melethil S

机构信息

Department of Pathology, School of Medicine, University of Missouri, Kansas City.

出版信息

Mol Chem Neuropathol. 1992 Aug;17(1):79-89. doi: 10.1007/BF03159983.

DOI:10.1007/BF03159983

PMID:1388451

Abstract

In the present study the acute effect of intravenous aluminum chloride (1 mg/kg) on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities of rats was investigated. Aluminum was found to cross the blood-brain barrier (BBB) as indicated by the detection of aluminum in the cerebrospinal fluid (CSF) 30 min after femoral vein injection. Two hours following aluminum injection, ChAT activity in the basal forebrain and hippocampus was significantly reduced by 30% and 22%, respectively, whereas no change was observed in the caudate nuclei. On the other hand, AChE activity was significantly increased by 45% in the caudate nuclei, whereas little change was observed in other brain areas. This report demonstrates that rapid transport of Al across the BBB, and the acute nature of Al neurotoxicity in rats.

摘要

在本研究中，研究了静脉注射氯化铝（1毫克/千克）对大鼠胆碱乙酰转移酶（ChAT）和乙酰胆碱酯酶（AChE）活性的急性影响。正如股静脉注射30分钟后在脑脊液（CSF）中检测到铝所表明的，铝能够穿过血脑屏障（BBB）。注射铝两小时后，基底前脑和海马体中的ChAT活性分别显著降低了30%和22%，而尾状核中未观察到变化。另一方面，尾状核中的AChE活性显著增加了45%，而其他脑区变化很小。本报告证明了铝在血脑屏障中的快速转运以及铝对大鼠神经毒性的急性性质。