Javorka K, Tomori Z
Physiol Bohemoslov. 1976;25(6):511-8.
The role of the sympathetic system in the development of bradycardia during nasal apnoea and the role of the sympathetic and parasympathetic system in the development of cardiovascular changes during and immediately after lung inflation were determined in anaesthetized rabbits. Transection of the cervical cord (C5-7) completely blocked the hypertensive response to chemical stimulation of the nasal mucosa. The degree of nasal bradycardia was 72% lower than in stimulation of the controls. Propranolol had no effect on the hypertensive reaction, but inhibited nasal bradycardia, which was 68% lower than in the controls. Lung inflation induced tachycardia, which was only non-significantly reduced by bilateral vagotomy. Vagotomy inhibited the bradycardiac response to removal of occlusion of the trachea and the subsequent rise in blood pressure, however. Cervical cord transection likewise did not reduce inflation-induced tachycardia, but it significantly influenced the heart rate during the second phase of prolonged inflation, when the heart is affected by hypoxia. Inflation-induced tachycardia was likewise not influenced by bilateral vagotomy associated with cervical cord transection. Similar cardiac responses also occur in the presence of the simple increase in pericardial pressure produced by left pneumothorax without lung inflation.
在麻醉兔中确定了交感神经系统在鼻呼吸暂停期间心动过缓发生中的作用，以及交感和副交感神经系统在肺充气期间及充气后立即发生的心血管变化中的作用。颈髓（C5 - 7）横断完全阻断了对鼻粘膜化学刺激的高血压反应。鼻性心动过缓的程度比刺激对照组时低72%。普萘洛尔对高血压反应无影响，但抑制了鼻性心动过缓，其程度比对照组低68%。肺充气诱发心动过速，双侧迷走神经切断术仅使其有不显著的降低。然而，迷走神经切断术抑制了对气管阻塞解除及随后血压升高的心动过缓反应。颈髓横断同样未降低充气诱发的心动过速，但在长时间充气的第二阶段，当心脏受到缺氧影响时，它显著影响心率。充气诱发的心动过速同样不受与颈髓横断相关的双侧迷走神经切断术的影响。在没有肺充气的情况下，由左气胸产生的心包压力单纯增加时也会出现类似的心脏反应。
