Cumberland N S, St Clair Roberts J, Arnold W S, Patel R K, Bowker C H
Queen Elizabeth Military Hospital, London, UK.
J Int Med Res. 1992 Jun;20(3):247-53. doi: 10.1177/030006059202000306.
A typhoid vaccine derived from the purified Vi capsular polysaccharide (CPS) antigen of Salmonella typhi was compared with a heat-killed whole-cell typhoid vaccine in 637 healthy male volunteers. The individuals were placed in three groups: group 1 received two doses of heat-killed whole-cell typhoid vaccine, at an interval of 28 days; group 2 received a single dose of typhoid Vi CPS vaccine followed after 28 days by water for injection; and group 3 received water for injection on the first occasion and a single dose of typhoid Vi CPS vaccine 28 days later. Local and systemic adverse reactions were recorded for 5 days following each injection. Subjects receiving the typhoid Vi CPS vaccine complained of fewer local adverse reactions on each of the first 3 days following immunization: on day 1, 18.6% of subjects given typhoid Vi CPS vaccine reported local reactions compared with 59.7% of those receiving heat-killed whole-cell vaccine (P less than 0.001). The percentage of subjects receiving the heat-killed whole-cell vaccine who complained of systemic reactions was more than twice that of subjects receiving the Vi CPS vaccine (7.9% and 3.4%, respectively, on day 1; P less than 0.01).
在637名健康男性志愿者中，对一种源自伤寒沙门氏菌纯化Vi荚膜多糖（CPS）抗原的伤寒疫苗与一种热灭活全细胞伤寒疫苗进行了比较。这些个体被分为三组：第1组间隔28天接种两剂热灭活全细胞伤寒疫苗；第2组接种一剂伤寒Vi CPS疫苗，28天后接种注射用水；第3组首次接种注射用水，28天后接种一剂伤寒Vi CPS疫苗。每次注射后记录5天的局部和全身不良反应。接种伤寒Vi CPS疫苗的受试者在免疫后的前3天中，每天抱怨的局部不良反应较少：第1天，接种伤寒Vi CPS疫苗的受试者中有18.6%报告有局部反应，而接种热灭活全细胞疫苗的受试者中有59.7%报告有局部反应（P<0.001）。抱怨有全身反应的接种热灭活全细胞疫苗的受试者比例是接种Vi CPS疫苗的受试者的两倍多（第1天分别为7.9%和3.4%；P<0.01）。
