破伤风治疗中作用于中枢的肌肉松弛剂。
Centrally acting muscle relaxants in tetanus.
作者信息
WEBSTER R A
出版信息
Br J Pharmacol Chemother. 1961 Dec;17(3):507-18. doi: 10.1111/j.1476-5381.1961.tb01137.x.
The anti-tetanus activity of a number of phenothiazine derivatives and other centrally acting muscle relaxants, such as mephenesin, dicyclopropyl ketoxime, 2-amino-6-methylbenzothiazole and meprobamate, has been determined in rabbits with experimental local tetanus. Structure-activity relationships were obtained for the phenothiazine derivatives and their anti-tetanus activity correlated with other central and peripheral properties. Both dicyclopropyl ketoxime and 2-amino-6-methyl-benzothiazole were twice as active as mephenesin. Meprobamate does not appear to be primarily a muscle relaxant of the mephenesin type.
在患有实验性局部破伤风的家兔中，已测定了多种吩噻嗪衍生物以及其他中枢性肌肉松弛剂（如甲丙氨酯、二环丙基酮肟、2-氨基-6-甲基苯并噻唑和眠尔通）的抗破伤风活性。得出了吩噻嗪衍生物的构效关系，且它们的抗破伤风活性与其他中枢和外周特性相关。二环丙基酮肟和2-氨基-6-甲基苯并噻唑的活性均是甲丙氨酯的两倍。眠尔通似乎并非主要的甲丙氨酯类型的肌肉松弛剂。
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