WILLIAMS J D, MATTHEWS G A, JUDD A W
Br J Ind Med. 1962 Jul;19(3):211-5. doi: 10.1136/oem.19.3.211.
A clinical trial of oral calcium disodium versenate (E.D.T.A.) in eight lead workers is described. A short course of versenate given while the men continued at work produced no side-effects. Complete overhaul of the processes and protective devices was made in the factory. Clinical, biochemical, and haematological improvement followed the removal of up to 250 mg. lead in each case. The mode of action and possible uses and abuses of oral versenate are discussed.
本文描述了对八名铅作业工人进行口服依地酸钙钠(E.D.T.A.)的临床试验。在工人继续工作的同时给予短疗程的依地酸钙钠未产生副作用。工厂对生产流程和防护设备进行了全面检修。在每例患者体内铅含量去除高达250毫克后,临床、生化及血液学指标均有改善。文中还讨论了口服依地酸钙钠的作用方式以及可能的用途和滥用情况。