坐骨神经中的乙酰胆碱样活性
ACETYLCHOLINE-LIKE ACTIVITY IN SCIATIC NERVE.
作者信息
CARLINI E A, GREEN J P
出版信息
Science. 1963 Sep 6;141(3584):901-2. doi: 10.1126/science.141.3584.901.
PMID:14043329
Abstract
Extracts of sciatic nerve exhibit acetylcholine-like activity that is only partly attributable to acetylcholine. The extracts show relatively greater activity on the rectus abdominis muscle of the frog than on the ileum of the guinea pig. To prevent the action of the extract on the frog rectus abdominis muscle, a greater concentration of d-tubocurarine is required than is necessary to prevent the action of known acetylcholine.
摘要
坐骨神经提取物表现出类似乙酰胆碱的活性，但这种活性仅部分归因于乙酰胆碱。该提取物对青蛙的腹直肌的活性比对豚鼠回肠的活性相对更强。为了阻止提取物对青蛙腹直肌的作用，所需的d -筒箭毒碱浓度要高于阻止已知乙酰胆碱作用所需的浓度。
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