UDENFRIEND S, ZALTZMAN-NIRENBERG P
Science. 1963 Oct 18;142(3590):394-6. doi: 10.1126/science.142.3590.394.
By administering C(14)-la-beled tyrosine or H(3)-labeled 3,4-dihy-droxyphenylalanine to guinea pigs it has been possible to achieve sufficient labeling of the norepinephrine and dopamine in the brain to permit measurement of their turnover rates. The half-life of brain dopamine was about 2.5 hours. The half-life of norepinephrine was about 4 hours, suggesting a rate of synthesis of at least 0.03 to 0.04, microg/g per hr or 2.4 microg/day for the whole guinea pig brain.
通过给豚鼠注射碳 - 14标记的酪氨酸或氢 - 3标记的3,4 - 二羟基苯丙氨酸，已能够使脑中的去甲肾上腺素和多巴胺获得足够的标记，从而可以测量它们的更新率。脑多巴胺的半衰期约为2.5小时。去甲肾上腺素的半衰期约为4小时，这表明整个豚鼠脑的合成速率至少为每小时0.03至0.04微克/克，即每天2.4微克。
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