YC8白血病细胞系对体外淋巴细胞反应性的抑制作用。
Inhibitory effect of YC8 leukaemia cell line on in vitro lymphocyte reactivity.
作者信息
Biasi G, Collavo D, Colombatti A, Chieco-Bianchi L
出版信息
Br J Cancer. 1977 May;35(5):528-36. doi: 10.1038/bjc.1977.86.
Abstract
Mitomycin-treated transplantable Moloney virus-induced lymphatic leukaemia cells (YC8) not only failed to stimulate normal allogeneic lymphocytes in one-way mixed leucocyte culture (MLC) but also exerted a strong inhibitory effect on the proliferative response of normal lymphocytes, in MLC and after stimulation by mitogens. Potentially inhibitory factors which could be released in the culture fluids by the YC8 cells were not found, but a YC8-derived adherent cell subpopulation was identified as being responsible for the in vitro suppression.
摘要
丝裂霉素处理过的可移植性莫洛尼病毒诱导的淋巴白血病细胞（YC8）不仅在单向混合淋巴细胞培养（MLC）中无法刺激正常同种异体淋巴细胞，而且对正常淋巴细胞在MLC中以及在有丝分裂原刺激后的增殖反应产生强烈抑制作用。未发现YC8细胞能在培养液中释放潜在的抑制因子，但已确定一个源自YC8的贴壁细胞亚群是体外抑制作用的原因。
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