Glucocorticoid-induced DNA fragmentation: role of protein-kinase-C activity.

作者信息

Migliorati G, Pagliacci M C, D'Adamio F, Crocicchio F, Nicoletti I, Riccardi C

机构信息

Istituto di Farmacologia Medica, Perugia University Medical School, Italy.

出版信息

Pharmacol Res. 1992 Sep;26 Suppl 2:5-9. doi: 10.1016/1043-6618(92)90574-u.

Glucocorticoid hormones (GCH) and IL-2 induce apoptotic cell death by a PKC-dependent mechanism. IL-4 counteracts apoptosis by inhibiting PKC activity. GCH and IL-2 show antagonistic effects on apoptosis when administered together. These data indicate that PKC activation in response to different stimuli can both enhance or reduce thymocyte survival.