怀孕、哺乳及怀孕-哺乳小鼠的 consummatory 行为与体重调节

Consummatory behaviors and weight regulation in pregnant, lactating, and pregnant-lactating mice.

作者信息

Biggerstaff S, Mann M

机构信息

Department of Psychology, University of Texas, Arlington 76019.

出版信息

Physiol Behav. 1992 Sep;52(3):485-91. doi: 10.1016/0031-9384(92)90335-y.

DOI:10.1016/0031-9384(92)90335-y

PMID:1409909

Abstract

Pregnant Rockland-Swiss (R-S) albino mice consumed significantly more food and water and gained significantly more weight between gestation days 8-17 compared to virgin R-S females maintained in isolation for a comparable period. Postpartum (days 1-10) patterns of ingestion and weight change among thelectomized (nipple-deprived) mouse dams provided with young did not differ significantly from those of virgin animals without young. Sham- and nonoperated dams received suckling stimulation from young and consumed about 100% more food than thelectomized or virgin females (Experiment 1). Pregnancy concurrent with lactation does not increase further the hyperphagic response of female mice. Nipple presence is the principle regulator of postpartum hyperphagia in lactating and simultaneously pregnant-lactating mouse dams (Experiment 2).

摘要

与在相同时间段单独饲养的未孕罗克兰-瑞士（R-S）白化雌性小鼠相比，怀孕的R-S白化小鼠在妊娠第8至17天期间消耗的食物和水显著更多，体重增加也显著更多。给接受了乳房切除（剥夺乳头）的母鼠幼崽后，产后（第1至10天）这些母鼠的摄食和体重变化模式与未育的未孕动物相比没有显著差异。假手术和未手术的母鼠受到幼崽的哺乳刺激，其食物消耗量比接受乳房切除的母鼠或未孕母鼠多约100%（实验1）。同时怀孕和哺乳并不会进一步增加雌性小鼠的食欲亢进反应。乳头的存在是哺乳期以及同时怀孕和哺乳的母鼠产后食欲亢进的主要调节因素（实验2）。