Dewar M A, Hall K, Perchalski J
Department of Community Health and Family Medicine, University of Florida College of Medicine, Gainesville.
Prim Care. 1992 Sep;19(3):589-606.
Population screening for cervical cancer resulted in significant reduction in the morbidity and mortality from cervical cancer. An increased understanding of the relationship of HPV infection with cervical cancer and the natural history of cervical cancer precursor lesions further solidifies and expands the biological basis for cervical cancer screening. Pap tests in asymptomatic women remain the cornerstone of cervical cancer screening. Clinicians should be cognizant of the significant false-negative rate of Pap smears. Meticulous attention to proper Pap smear technique is necessary to maximize the sensitivity of the test. Further research is needed to establish the role of cervicography and HPV DNA hybridization techniques in cervical cancer screening.
宫颈癌的人群筛查显著降低了宫颈癌的发病率和死亡率。对人乳头瘤病毒（HPV）感染与宫颈癌关系以及宫颈癌前病变自然史的进一步了解，进一步巩固和拓展了宫颈癌筛查的生物学基础。对无症状女性进行巴氏试验仍然是宫颈癌筛查的基石。临床医生应认识到巴氏涂片存在显著的假阴性率。必须严格注意正确的巴氏涂片技术，以最大限度提高检测的敏感性。还需要进一步研究以确定宫颈图像检查和HPV DNA杂交技术在宫颈癌筛查中的作用。
