通过铁59全身计数法对月经失血及其他失血情况以及由此导致的缺铁性贫血进行的研究。
THE STUDY OF MENSTRUAL AND OTHER BLOOD LOSS, AND CONSEQUENT IRON DEFICIENCY, BY FE59 WHOLE-BODY COUNTING.
作者信息
PRICE D C, FORSYTH E M, COHN S H, CRONKITE E P
出版信息
Can Med Assoc J. 1964 Jan 11;90(2):51-4.
A recently established method of in vivo radioiron investigation in humans, employing a steel-room whole-body counter, has been applied to the study of Fe(59) absorption and loss in seven menstruating women, six with menorrhagia and hypochromic anemia. All six were found by this method to be iron-deficient, having radioiron absorptions of 53.7-97.5% (normal 5.7-24.7%). With almost 100% radioiron incorporation into the red-cell mass, subsequent drops in Fe(59) activity, when correlated with monthly menses, revealed estimated menstrual blood losses of 110-550 c.c. The single normal patient absorbed 19.6% of the tracer, with only 33-59 c.c. menstrual blood loss. Additional applications of the technique in assessing episodic (e.g., epistaxis) and continuous (e.g., gastrointestinal) blood loss are also described. The method would appear eminently applicable to the study of any hypochromic anemia of hemorrhagic origin.
一种最近建立的用于人体体内放射性铁研究的方法，采用钢室全身计数器，已应用于对7名月经女性、6名月经过多和低色素性贫血患者的铁（59）吸收和流失的研究。通过这种方法发现，所有6名患者都缺铁，放射性铁吸收率为53.7 - 97.5%（正常为5.7 - 24.7%）。几乎100%的放射性铁掺入红细胞群，随后铁（59）活性的下降与每月月经相关，显示估计月经失血量为110 - 550立方厘米。唯一的正常患者吸收了19.6%的示踪剂，月经失血量仅为33 - 59立方厘米。还描述了该技术在评估间歇性（如鼻出血）和持续性（如胃肠道）失血方面的其他应用。该方法似乎非常适用于研究任何出血性起源的低色素性贫血。
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