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基于电渗作用的突触“学习”:一种理论

SYNAPTIC "LEARNING" DUE TO ELECTROOSMOSIS: A THEORY.

作者信息

RANCK J B

出版信息

Science. 1964 Apr 10;144(3615):187-9. doi: 10.1126/science.144.3615.187.

Abstract

Since the interstitial water of the central nervous system is in narrow channels between cells that have surface charge, electroosmotic flow of water should accompany current flow. Current density is high close to an excitatory postsynaptic membrane and the electroosmotic effect must be significant. Simultaneity relationships between action potentials in pre- and postsynaptic cells affect postsynaptic membrane current density and modulate the effect in a way which should produce "learning."

摘要

由于中枢神经系统的间质水存在于具有表面电荷的细胞之间的狭窄通道中,水的电渗流应伴随电流流动。在兴奋性突触后膜附近电流密度很高,电渗效应必定很显著。突触前和突触后细胞动作电位之间的同时性关系会影响突触后膜电流密度,并以一种应能产生“学习”的方式调节这种效应。

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