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[螺旋形细菌在成年牛真胃溃疡病因学中的可能意义]

[Possible significance of spiral-shaped bacteria in the etiology of abomasal ulcers in adult cattle].

作者信息

Haringsma P C, Mouwen J M

机构信息

Pathologisch Instituut, Fakulteit der Diergeneeskunde, Utrecht.

出版信息

Tijdschr Diergeneeskd. 1992 Sep 1;117(17):485-7.

PMID:1412361
Abstract

Enzyme-chemical and histological evaluations were used to examine the abomasal mucosa of adult cattle with or without mucosal lesions of the corpus. Urease activity was detected with the CLO (Campylobacter-like organisms) test in the abomasal mucosa of all cattle except one, which had mucosal lesions. Spiral-shaped bacteria were visualised histologically in the mucus layer, with the highest number being found in the pars pylorica. Variable amounts of intra-epithelial mucin were found in the corpus and pars pylorica of both test and control cattle. Most inflammatory cells were found in the lamina propria of the pars pylorica. It is suggested that spiral-shaped bacteria, together with a diminished mucosal barrier, play a role in the pathogenesis of abomasal ulcers in adult cattle.

摘要

采用酶化学和组织学评估方法,对成年牛有或无胃体黏膜损伤的皱胃黏膜进行检查。除1头有黏膜损伤的牛外,所有牛的皱胃黏膜均通过CLO(类弯曲杆菌)试验检测到脲酶活性。组织学观察发现,黏液层中有螺旋形细菌,幽门部数量最多。试验组和对照组牛的胃体和幽门部均发现不同数量的上皮内黏蛋白。大多数炎性细胞见于幽门部固有层。提示螺旋形细菌与黏膜屏障减弱共同在成年牛皱胃溃疡的发病机制中起作用。

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