ROBERTS K E
Calif Med. 1964 Mar;100(3):160-4.
The mechanism whereby sulfonamyl diuretics are effective is through the blockage of the renal tubular reabsorption of chloride. The excretion of sodium, potassium and water is a passive one to maintain ionic equilibrium. Chlorothiazide has been shown to be almost ineffective as a diuretic agent per se. Although it does block a moiety of the renal tubular reabsorption of bicarbonate, the effect is merely a transient one.
磺酰胺类利尿剂发挥作用的机制是通过阻断肾小管对氯离子的重吸收。钠、钾和水的排泄是被动的,以维持离子平衡。氯噻嗪本身作为一种利尿剂几乎无效。尽管它确实能阻断肾小管对碳酸氢盐的部分重吸收,但这种作用只是暂时的。