干扰素：无细胞系统中作用的选择性和特异性

INTERFERONS: SELECTIVITY AND SPECIFICITY OF ACTION IN CELL-FREE SYSTEMS.

作者信息

GLASKY A J, SIMON L, HOLPER J C

出版信息

Science. 1964 Jun 26;144(3626):1581-3. doi: 10.1126/science.144.3626.1581.

DOI:10.1126/science.144.3626.1581

Abstract

The inhibition by interferons of viral replication was studied with cell-free preparations of the enzyme RNA synthetase derived from calf kidney cells infected with influenza virus and from chick embryo fibroblasts infected with Newcastle disease virus. Calf, mouse, and chicken interferons inhibited these enzymes with the same characteristic species specificity observed in tissue culture. A mechanism of action is proposed.

摘要

利用从感染流感病毒的小牛肾细胞以及感染新城疫病毒的鸡胚成纤维细胞中提取的无细胞RNA合成酶制剂，研究了干扰素对病毒复制的抑制作用。小牛、小鼠和鸡的干扰素对这些酶的抑制作用，与在组织培养中观察到的具有相同特征的种属特异性一致。本文提出了一种作用机制。