单克隆抗体在造血系统癌症的研究与治疗中的应用

Monoclonal antibodies in the study and therapy of hematopoietic cancers.

作者信息

Matthews D C, Smith F O, Bernstein I D

机构信息

Fred Hutchinson Cancer Research Center, Department of Pediatrics, University of Washington, Seattle 98104.

出版信息

Curr Opin Immunol. 1992 Oct;4(5):641-6. doi: 10.1016/0952-7915(92)90040-l.

DOI:10.1016/0952-7915(92)90040-l

PMID:1418732

Abstract

Recent advances utilizing monoclonal antibodies to phenotype acute leukemias have revealed no prognostic significance of the expression of lymphoid-associated antigens by acute myeloid leukemia blasts and conflicting results regarding 'biphenotypic' acute myeloid leukemia. Several studies treating patients with refractory lymphoma with immunotoxins reported encouraging results but significant production of anti-mouse or anti-toxin antibody. Radiolabeled antibodies that react with panhematopoietic antigens have delivered selective radiation to marrow, spleen and lymph nodes in animal models and are being used in Phase I studies of marrow transplantation for acute leukemia.

摘要

利用单克隆抗体对急性白血病进行表型分析的最新进展表明，急性髓细胞白血病原始细胞中淋巴相关抗原的表达没有预后意义，并且关于“双表型”急性髓细胞白血病的结果相互矛盾。几项用免疫毒素治疗难治性淋巴瘤患者的研究报告了令人鼓舞的结果，但产生了大量抗小鼠或抗毒素抗体。与全造血抗原反应的放射性标记抗体已在动物模型中将选择性辐射传递至骨髓、脾脏和淋巴结，并且正用于急性白血病骨髓移植的I期研究。