Ribak J, Selikoff I J
Environmental Sciences Laboratory, Mount Sinai School of Medicine, City University of New York.
Br J Ind Med. 1992 Oct;49(10):732-5. doi: 10.1136/oem.49.10.732.
Malignant mesothelioma is a lethal disease. It is rare in the general population; however, workers exposed to asbestos suffer significant burdens of the neoplasm. The survival time of 457 consecutive fatal cases of pleural and peritoneal mesothelioma that occurred among 17,800 asbestos insulation workers observed prospectively from 1 January 1967 to 1 January 1987 was studied. Mean survival time from initial presentation of the disease to death was 11.4 months for the pleural mesothelioma patients compared with 7.4 months for the peritoneal group. This difference was statistically significant. Mean survival time from diagnosis to death was shorter for both groups of patients: 8.4 months for pleural mesothelioma v 5.8 months for the peritoneal cases. In conclusion, survival time in mesothelioma patients is short; most die within a year from the onset of the initial symptoms. No effective therapy is yet available.
恶性间皮瘤是一种致命疾病。在普通人群中较为罕见；然而，接触石棉的工人患这种肿瘤的负担很重。对1967年1月1日至1987年1月1日期间前瞻性观察的17800名石棉绝缘工人中连续发生的457例致命性胸膜和腹膜间皮瘤病例的生存时间进行了研究。胸膜间皮瘤患者从疾病初发至死亡的平均生存时间为11.4个月，而腹膜间皮瘤组为7.4个月。这种差异具有统计学意义。两组患者从诊断到死亡的平均生存时间均较短：胸膜间皮瘤为8.4个月，腹膜间皮瘤为5.8个月。总之，间皮瘤患者的生存时间较短；大多数患者在出现初始症状后的一年内死亡。目前尚无有效的治疗方法。
