大鼠胎儿轴突生长锥中5-羟色胺的分子识别系统：摄取与高亲和力结合。

A molecular recognizing system of serotonin in rat fetal axonal growth cones: uptake and high affinity binding.

作者信息

Mercado R, Hernández J

机构信息

Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados del IPN, México, DF, México.

出版信息

Brain Res Dev Brain Res. 1992 Sep 18;69(1):133-7. doi: 10.1016/0165-3806(92)90130-o.

DOI:10.1016/0165-3806(92)90130-o

PMID:1424085

Abstract

Axonal growth cone particles (AGCP) isolated from prenatal and postnatal rat brain had different high-affinity 5-HT uptake characteristics. In postnatal AGCP the uptake behaves as in the adult rat brain, while in the prenatal AGCP the uptake characteristics seem to be in a transitional stage. Also in prenatal AGCP we observed specific, high-affinity 5-HT binding sites. These results support the idea of an important role for 5-HT during axogenesis.

摘要

从产前和产后大鼠脑中分离出的轴突生长锥颗粒（AGCP）具有不同的高亲和力5-羟色胺摄取特性。在产后AGCP中，摄取情况与成年大鼠脑相同，而在产前AGCP中，摄取特性似乎处于过渡阶段。在产前AGCP中我们还观察到特异性的、高亲和力的5-羟色胺结合位点。这些结果支持了5-羟色胺在轴突发生过程中起重要作用这一观点。