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泪囊的化脓性肉芽肿

Pyogenic granulomas of the lacrimal sac.

作者信息

Asiyo M N, Stefani F H

机构信息

Kenyatta National Hospital, Nairobi, Kenya.

出版信息

Eye (Lond). 1992;6 ( Pt 1):97-101. doi: 10.1038/eye.1992.20.

Abstract

Eight cases of pyogenic granulomas of the lacrimal sac are reported. The clinical symptoms were consistent with chronic dacryocystitis which was unresponsive to previous probing and antibiotics. Extirpation of the sacs was done because of dacryocystocoele, pyocoele, or fistula formation through the skin. Trauma and inflammation were thought to have contributed to the growth of the pyogenic granulomas. The histopathological examination revealed nonspecific granulomas consisting of well vascularised, friable tissue of a myxomatous nature containing an infiltration of lymphocytes, plasma cells, and a few eosinophils. Over the granulomas an epithelial layer of cells is stretched showing no signs of dysplasia or neoplastic growth. The term 'lobular capillary hemangioma' has been suggested to describe lesions morphologically similar to those observed in the study. These masses made up 53.3% of a total of 15 lacrimal sac tumour biopsy specimens examined over a period of 10 years (1979-1989). The few reported cases of primary lacrimal sac tumour of non-epithelial origin suggest that they make up a large minority of the lacrimal sac tumours. A review shows that relatively few of these lesions have been described in recent English literature but these growths are probably not being as consistently reported as primary epithelial tumours.

摘要

本文报告了8例泪囊化脓性肉芽肿。临床症状与慢性泪囊炎相符,既往泪道探通及使用抗生素治疗均无效。因泪囊膨出、脓性囊肿或皮肤瘘形成而进行泪囊摘除术。创伤和炎症被认为是化脓性肉芽肿生长的原因。组织病理学检查显示为非特异性肉芽肿,由血管丰富、质地脆的黏液瘤样组织构成,伴有淋巴细胞、浆细胞浸润及少量嗜酸性粒细胞。肉芽肿表面有一层上皮细胞覆盖,未见发育异常或肿瘤性生长迹象。有人建议用“小叶状毛细血管瘤”来描述形态学上与本研究中观察到的病变相似的肿物。在10年(1979 - 1989年)期间检查的15例泪囊肿瘤活检标本中,这些肿物占53.3%。少数已报道的非上皮源性原发性泪囊肿瘤病例表明,它们在泪囊肿瘤中占很大比例。一项综述显示,近期英文文献中对这些病变的描述相对较少,但这些肿物的报道可能不如原发性上皮性肿瘤那样一致。

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