刺激胃幽门腺区诱导的胰腺分泌

PANCREATIC SECRETION INDUCED BY STIMULATION OF THE PYLORIC GLAND AREA OF THE STOMACH.

作者信息

PRESHAW R M, COOKE A R, GROSSMAN M I

出版信息

Science. 1965 Jun 4;148(3675):1347-8. doi: 10.1126/science.148.3675.1347.

DOI:10.1126/science.148.3675.1347

Abstract

Pure gastrin I of Gregory and Tracy stimulated secretion not only of gastric acid but also of pancreatic fluid and protein material. Similarly, endogenous release of gastrin from a transplanted pouch of the pyloric gland area of the stomach, initiated by irrigation with solutions of acetylcholine, stimulated gastric acid secretion and pancreatic flow and protein output in dogs with fistulas of both organs. The effect on the pancreas, like that on the stomach, was inhibited by acidification of the acetylcholine solution.

摘要

格雷戈里和特雷西的纯胃泌素I不仅刺激胃酸分泌，还刺激胰液和蛋白质物质的分泌。同样，用乙酰胆碱溶液冲洗移植的胃幽门腺区囊袋引发内源性胃泌素释放，刺激了患有两个器官瘘管的犬的胃酸分泌、胰液分泌和蛋白质排出。对胰腺的作用，与对胃的作用一样，被乙酰胆碱溶液的酸化所抑制。