BURLANT L, DATTA P, GEST H
Science. 1965 Jun 4;148(3675):1351-3. doi: 10.1126/science.148.3675.1351.
Amino acids of the aspartic acid family are synthesized in bacteria through a multistep branched pathway. In the photosynthetic bacterium Rhodopseudomonas capsulatus, the enzyme that catalyzes the first step is specifically inhibited by a combination of two end-product amino acids. Evidence is presented for operation of this kind of "concerted" feedback control as a regulatory device in growing cells.
天冬氨酸家族的氨基酸在细菌中通过多步分支途径合成。在光合细菌荚膜红假单胞菌中,催化第一步反应的酶会被两种终产物氨基酸的组合特异性抑制。本文提供了证据,证明这种“协同”反馈控制在生长细胞中作为一种调节机制发挥作用。