Inoue T, Kawasaki H, Shiraishi S, Takasaki M
Department of Anesthesiology, Miyazaki Medical College.
Masui. 1992 Sep;41(9):1414-8.
It was previously reported that high-dose (50 micrograms.kg-1) fentanyl anesthesia had no effect on auditory brainstem response (ABR). However, the effect of the dose of 100 micrograms.kg-1 of fentanyl is unknown. We examined the effects of the dose of 50 micrograms.kg-1 and 100 micrograms.kg-1 of fentanyl on ABRs in 10 patients scheduled for cardiovascular surgery. No significant change was observed immediately after infusion of 50 micrograms.kg-1 of fentanyl, but peak latencies of waves I, III and V were significantly prolonged and the amplitude of wave V was significantly decreased immediately after infusion of 100 micrograms.kg-1 of fentanyl. The interpeak latencies of I-III and I-V were not affected. Therefore, prolongations of latencies of waves III and V were due to the change of latency of wave I. These results demonstrate that high-dose (100 micrograms.kg-1) fentanyl anesthesia depresses the peripheral auditory perception but dose not depress the central conduction.
先前有报道称，高剂量（50微克·千克-1）芬太尼麻醉对听性脑干反应（ABR）无影响。然而，100微克·千克-1剂量的芬太尼的作用尚不清楚。我们研究了50微克·千克-1和100微克·千克-1剂量的芬太尼对10例计划进行心血管手术患者ABR的影响。输注50微克·千克-1芬太尼后立即未观察到明显变化，但输注100微克·千克-1芬太尼后，I、III和V波的峰潜伏期显著延长，V波振幅显著降低。I-III和I-V的峰间潜伏期未受影响。因此，III和V波潜伏期的延长是由于I波潜伏期的改变。这些结果表明，高剂量（100微克·千克-1）芬太尼麻醉会抑制外周听觉感知，但不会抑制中枢传导。
