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个体对药物和安慰剂的反应存在持续差异。

Consistent differences in individual reactions to drugs and dummies.

作者信息

JOYCE C R

出版信息

Br J Pharmacol Chemother. 1959 Dec;14(4):512-21. doi: 10.1111/j.1476-5381.1959.tb00958.x.

DOI:10.1111/j.1476-5381.1959.tb00958.x
PMID:14408028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1481910/
Abstract

The tendency of some individuals to report changes of physical and mental state after taking pharmacologically inert substances has been investigated experimentally. In a class of healthy medical students, those individuals who reported symptoms and those who did not made significantly different scores on a number of behavioural tests. The likely reactions of the members of a second class (containing none of the previous participants) to dummies were then predicted from their scores on the same tests, some of which were found to be much more efficient predictors than would have been expected by chance. Some implications for further research and for clinical medicine are discussed.

摘要

对一些人在服用药理惰性物质后报告身心状态变化的倾向进行了实验研究。在一组健康的医学生中,报告有症状的人和未报告症状的人在多项行为测试中的得分有显著差异。然后根据第二类学生(不包括之前的参与者)在相同测试中的得分,预测他们对安慰剂的可能反应,其中一些测试被发现是比随机预期更有效的预测指标。讨论了对进一步研究和临床医学的一些启示。

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Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses.儿茶酚-O-甲基转移酶Val158Met基因多态性与体感放大和反安慰剂反应相关。
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Tranquillizers.镇静剂
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Psychological effects of medication. Differences between physicians as revealed by clinical trials.药物的心理效应。临床试验揭示的医生之间的差异。
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7
Experiments with control substances.对照物质的实验。
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本文引用的文献

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Individual Variation in Response to Drugs.药物反应的个体差异。
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