嘌呤的酶促氧化机制。

Mechanism of enzymatic oxidation of purines.

作者信息

KWIETNY H, LEVIN G, BERGMANN F, BROWN D J

出版信息

Science. 1959 Sep 18;130(3377):711-2. doi: 10.1126/science.130.3377.711-a.

DOI:10.1126/science.130.3377.711-a

Abstract

Tautomeric forms of 2-hydroxypurine, in which the structure has been fixed by introduction of an N-methyl group, are oxidized differently by xanthine oxidase. The 1-methyl derivative is attacked at position 8 and the 3-methyl derivative at carbon atom 6. These observations indicate that 2-hydroxypurine itself reacts in a tautomeric form, corresponding to the structure of its 1-methyl derivative.

摘要

2-羟基嘌呤的互变异构体形式，其结构已通过引入N-甲基基团得以固定，被黄嘌呤氧化酶氧化的方式有所不同。1-甲基衍生物在第8位被攻击，3-甲基衍生物在碳原子6处被攻击。这些观察结果表明，2-羟基嘌呤本身以一种互变异构体形式发生反应，该形式与其1-甲基衍生物的结构相对应。