两栖类变态的生化研究。I. 甲状腺素对蝌蚪蛋白质合成的影响。
Biochemical studies on amphibian metamorphosis. I. The effect of thyroxine on protein synthesis in the tadpole.
作者信息
PAIK W K, COHEN P P
出版信息
J Gen Physiol. 1960 Mar;43(4):683-96. doi: 10.1085/jgp.43.4.683.
Abstract
Thyroxine has been shown to accelerate the synthesis of carbamyl phosphate synthetase in the liver of Rana catesbeiana. Stimulation of carbamyl phosphate synthetase synthesis by thyroxine appears to be relatively specific because of the following observations: (1) succinoxidase activity decreased during the time that carbamyl phosphate synthetase increased; (2) liver catalase responded more slowly than carbamyl phosphate synthetase to thyroxine; (3) the ratio of biochemical changes/morphological changes was greatly altered during thyroxine-induced metamorphosis. The relationships between the concentration of thyroxine and (1) temperature; (2) duration of exposure of the tadpole to thyroxine; and (3) the activity of carbamyl phosphate synthetase during the induced synthesis of carbamyl phosphate synthetase by thyroxine are discussed. Chloramphenicol and thiouracil partly counteracted the effect of thyroxine on the synthesis of carbamyl phosphate synthetase.
摘要
已证明甲状腺素能加速牛蛙肝脏中氨甲酰磷酸合成酶的合成。甲状腺素对氨甲酰磷酸合成酶合成的刺激似乎具有相对特异性，原因如下：（1）在氨甲酰磷酸合成酶增加的同时，琥珀酸氧化酶活性降低；（2）肝脏过氧化氢酶对甲状腺素的反应比氨甲酰磷酸合成酶更慢；（3）在甲状腺素诱导的变态过程中，生化变化与形态变化的比例发生了很大改变。文中讨论了甲状腺素浓度与（1）温度；（2）蝌蚪接触甲状腺素的持续时间；以及（3）甲状腺素诱导氨甲酰磷酸合成酶合成过程中氨甲酰磷酸合成酶活性之间的关系。氯霉素和硫脲嘧啶部分抵消了甲状腺素对氨甲酰磷酸合成酶合成的影响。
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Biochemical studies on amphibian metamorphosis. I. The effect of thyroxine on protein synthesis in the tadpole.两栖类变态的生化研究。I. 甲状腺素对蝌蚪蛋白质合成的影响。
J Gen Physiol. 1960 Mar;43(4):683-96. doi: 10.1085/jgp.43.4.683.
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