Funakoshi T, Furushima K, Shimada H, Kojima S
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Biochem Int. 1992 Oct;28(1):113-9.
Some of the lanthanides, the rare earth metals, lanthanum (La), cerium (Ce), neodymium (Nd), samarium (Sm), terbium (Tb), dysprosium (Dy), erbium (Er) and ytterbium (Yb) prolonged the clotting time of normal human plasma in a dose-dependent manner when clotting was induced either by thromboplastin or by kaolin in the presence of cephalin and Ca2+. They also prolonged the activated factor X induced clotting time of platelet-rich plasma. The amidolytic activities of activated factor X and thrombin progressively decreased with increasing amount of rare earth metals. These results suggested that the rare earth metals appear to show their anticoagulant effect with mechanisms in part the inhibition of the enzymatic activities of both activated factor X and thrombin.
一些镧系元素，即稀土金属，镧（La）、铈（Ce）、钕（Nd）、钐（Sm）、铽（Tb）、镝（Dy）、铒（Er）和镱（Yb），当在脑磷脂和Ca2+存在的情况下，通过凝血活酶或高岭土诱导凝血时，它们以剂量依赖的方式延长正常人血浆的凝血时间。它们还延长了富含血小板血浆中活化因子X诱导的凝血时间。随着稀土金属量的增加，活化因子X和凝血酶的酰胺水解活性逐渐降低。这些结果表明，稀土金属似乎通过部分抑制活化因子X和凝血酶的酶活性来显示其抗凝作用。
