Conte U, Maggi L, Giunchedi P, La Manna A
Dipartimento di Chimica Farmaceutica, Università di Pavia, Italy.
Boll Chim Farm. 1992 May;131(5):199-204.
Polymeric barriers applied by compression have already been used to control drug release rate from matrix tablets. In this paper, polymeric barrier layers, used to prepare and develop a new device able to release the drug after a programmable period of time, are described. Some matrix core formulations, containing Trapidil or Sodium Diclofenac as a model drug, were dry-coated using either a swellable or an erodible shell. This coating prevents drug release from the core until the polymeric layer is not completely eroded or swollen. The time-lag can be modified by changing the barrier formulation and/or the coating thickness. Also drug release profiles (release rate and kinetics), can be widely modified changing the barrier layer characteristics.
通过压缩施加的聚合物屏障已被用于控制基质片剂的药物释放速率。本文描述了用于制备和开发一种能够在可编程时间段后释放药物的新装置的聚合物屏障层。一些含有曲匹地尔或双氯芬酸钠作为模型药物的基质核心制剂，使用可溶胀或可侵蚀的外壳进行干包衣。这种包衣可防止药物从核心释放，直到聚合物层未完全侵蚀或溶胀。通过改变屏障制剂和/或包衣厚度可以改变时间滞后。同样，通过改变屏障层特性，药物释放曲线（释放速率和动力学）也可以被广泛改变。
