经阴道配子输卵管内移植术和胚胎输卵管内移植术。

Transvaginal gamete intra-fallopian transfer and embryo intra-fallopian transfer.

作者信息

Lisse K, Sydow P, Scheiber I, Klare P

机构信息

Department of Obstetrics and Gynaecology, Humboldt University Medical Centre Charité, Berlin, FRG.

出版信息

Hum Reprod. 1992 Jun;7 Suppl 1:111-3. doi: 10.1093/humrep/7.suppl_1.111.

DOI:10.1093/humrep/7.suppl_1.111

PMID:1447363

Abstract

This study describes the conduct and results of a recently developed technique for transvaginal catheterization of the Fallopian tube in order to transfer gametes or early embryos. Transvaginal gamete intra-Fallopian transfer (TV-GIFT) was performed in 46 patients after stimulation with human menopausal gonadotrophin (HMG) and human chorionic gonadotrophin (HCG) and transvaginal oocyte retrieval. This resulted in 11 (23.9%) pregnancies. Eight patients delivered healthy children, including one set of twins. Two patients had abortions at 8 and 11 weeks of gestation and one had an ectopic pregnancy. In a first series of 11 women, oocytes were fertilized in vitro and a maximum of three embryos at the 2- to 8-cell stages were transferred into one tube. Three of the 11 cycles with tubal embryo-stage transfer' (TV-TEST) resulted in clinical pregnancy.

摘要

本研究描述了一种最近开发的经阴道输卵管插管技术的操作过程及结果，该技术用于配子或早期胚胎的移植。46例患者在接受人绝经期促性腺激素（HMG）和人绒毛膜促性腺激素（HCG）刺激及经阴道取卵后，进行了经阴道输卵管内配子移植（TV-GIFT）。这导致了11例（23.9%）妊娠。8例患者分娩出健康婴儿，其中包括一对双胞胎。2例患者在妊娠8周和11周时流产，1例发生异位妊娠。在第一组11名女性中，卵母细胞在体外受精，最多将3个处于2至8细胞阶段的胚胎移植到一侧输卵管。11个输卵管胚胎期移植周期（TV-TEST）中有3个导致临床妊娠。