Hoshino E, Ohga H, Sasaki T
Third Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Sep;30(9):1624-31.
The circadian rhythm of respiratory function was examined in normal males and asthmatic subjects. In both groups, maximal flow decreased in the early morning. The major factor contributing to the circadian change in V50 was lung elastic recoil pressure in normal males and upstream resistance in asthmatic subjects. In some asthmatic patients, beclomethasone inhaled in the afternoon and at night was more effective than in the morning in increasing both the circadian maximal and minimal peak expiratory flow rates. This indicates the importance of chronotherapy in asthma.
对正常男性和哮喘患者的呼吸功能昼夜节律进行了研究。在两组中，最大流量均在清晨下降。导致正常男性V50昼夜变化的主要因素是肺弹性回缩压，而哮喘患者则是上游阻力。在一些哮喘患者中，下午和晚上吸入倍氯米松在增加昼夜最大和最小呼气峰值流速方面比早上更有效。这表明时间疗法在哮喘治疗中的重要性。
