Li C Y, Yam L T
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.
Acta Cytol. 1992 Nov-Dec;36(6):963-7.
Serial studies were done on cerebrospinal fluid (CSF) from a patient with sarcoidosis involving the meninges. Initially when the disease was active, the CSF protein was increased and glucose decreased. The number of cells in the CSF was moderately increased, and many mononuclear cells were present. Cytologic studies of the CSF showed many normal and some atypical lymphocytes. Immunochemical studies showed that most of these lymphocytes were T cells, with T-helper cells predominating over T-suppressor cells by a ratio of 3.92; B-lymphocytes were polyclonal. Subsequent studies of the CSF over the following three and one-half years showed that the protein and glucose content and the cell counts in the fluid did not correlate well with the activity of the disease. The number of atypical lymphocytes seemed to be a more useful marker of disease activity in the patient. Cytologic studies, when interpreted within the context of other CSF and clinical findings, are useful for the assessment of patients with sarcoidosis involving the meninges.
对一名患有累及脑膜结节病患者的脑脊液（CSF）进行了系列研究。最初，当疾病处于活动期时，脑脊液蛋白升高而葡萄糖降低。脑脊液中的细胞数量适度增加，且存在许多单核细胞。脑脊液的细胞学研究显示有许多正常淋巴细胞和一些非典型淋巴细胞。免疫化学研究表明，这些淋巴细胞大多数是T细胞，其中辅助性T细胞与抑制性T细胞的比例为3.92，以辅助性T细胞为主；B淋巴细胞呈多克隆性。在接下来的三年半时间里对脑脊液进行的后续研究表明，脑脊液中的蛋白质和葡萄糖含量以及细胞计数与疾病活动度并无良好的相关性。非典型淋巴细胞的数量似乎是该患者疾病活动度更有用的标志物。在结合其他脑脊液和临床检查结果进行解读时，细胞学研究对于评估患有累及脑膜结节病的患者很有用。
