Tkachenko B I, Evlakhov V I, Poiasov I Z
Institute of Experimental Medicine, Russian Acad. Med. Sci., St. Petersburg, 197376, Acad. Pavlov St., 12, Russia.
Ross Fiziol Zh Im I M Sechenova. 2003 May;89(5):533-42.
Changes of the right atrial pressure and systemic haemodynamics following action of catecholamines (epinephrine and norepinephrine) were studied in acute experiments on anaesthetised mongrel cats with artificial lung ventilation and opened chest. Maximal changes of the right atrial pressure took place on the 12th-16th second following catecholamine administration. In that case, the atrial pressure could be decreased or increased. At the moment of maximal changes of the right atrial pressure, the venous return and the right ventricular myocardial contractility (the first derivative of the right atrial pressure, dP/dt max) increased more if the right atrial pressure decreased, as compared with the animals whose right atrial pressure augmented. The findings suggest that at the time of the maximal changes of the right atrial pressure following action of catecholamines, there may be a direct connection of the right atrial pressure with interrelation of venous return and the right ventricular contractility. The right atrial pressure, however, is a dependent parameter but it does not determine the venous return.
在人工肺通气和开胸的麻醉杂种猫急性实验中，研究了儿茶酚胺（肾上腺素和去甲肾上腺素）作用后右心房压力和全身血流动力学的变化。给予儿茶酚胺后第12 - 16秒时右心房压力发生最大变化。在这种情况下，心房压力可能降低或升高。与右心房压力升高的动物相比，当右心房压力降低时，在右心房压力发生最大变化的时刻，静脉回流量和右心室心肌收缩力（右心房压力的一阶导数，dP/dt max）增加得更多。研究结果表明，在儿茶酚胺作用后右心房压力发生最大变化时，右心房压力可能与静脉回流量和右心室收缩力的相互关系存在直接联系。然而，右心房压力是一个依赖参数，但它并不决定静脉回流量。
