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1
Negative selection imparts peptide specificity to the mature T cell repertoire.
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11565-70. doi: 10.1073/pnas.1934636100. Epub 2003 Sep 22.
2
How the T cell repertoire becomes peptide and MHC specific.
Cell. 2005 Jul 29;122(2):247-60. doi: 10.1016/j.cell.2005.05.013.
3
T cells and their eons-old obsession with MHC.
Immunol Rev. 2012 Nov;250(1):49-60. doi: 10.1111/imr.12004.
4
Functional evidence for TCR-intrinsic specificity for MHCII.
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3000-5. doi: 10.1073/pnas.1518499113. Epub 2016 Feb 1.
7
The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.
J Immunol. 2014 Aug 15;193(4):1778-86. doi: 10.4049/jimmunol.1400532. Epub 2014 Jul 11.
8
Pre-TCR ligand binding impacts thymocyte development before αβTCR expression.
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8373-8. doi: 10.1073/pnas.1504971112. Epub 2015 Jun 8.
9
Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.
J Immunol. 2014 Jun 15;192(12):6071-82. doi: 10.4049/jimmunol.1303209. Epub 2014 May 9.

引用本文的文献

1
Is the exquisite specificity of lymphocytes generated by thymic selection or due to evolution?
Front Immunol. 2024 Mar 25;15:1266349. doi: 10.3389/fimmu.2024.1266349. eCollection 2024.
2
I-A β56/57 polymorphisms regulate non-cognate negative selection to CD4 T cell orchestrators of type 1 diabetes.
Nat Immunol. 2023 Apr;24(4):652-663. doi: 10.1038/s41590-023-01441-0. Epub 2023 Feb 20.
3
CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope.
J Exp Med. 2021 Oct 4;218(10). doi: 10.1084/jem.20210785. Epub 2021 Aug 19.
4
TCRα reporter mice reveal contribution of dual TCRα expression to T cell repertoire and function.
Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32574-32583. doi: 10.1073/pnas.2013188117. Epub 2020 Dec 7.
5
Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.
J Immunol. 2017 Jan 1;198(1):257-269. doi: 10.4049/jimmunol.1601200. Epub 2016 Nov 16.
6
Survivin-specific T cell receptor targets tumor but not T cells.
J Clin Invest. 2015 Jan;125(1):157-68. doi: 10.1172/JCI75876. Epub 2014 Nov 21.
7
Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14840-5. doi: 10.1073/pnas.1416864111. Epub 2014 Sep 29.
8
Revisiting thymic positive selection and the mature T cell repertoire for antigen.
Immunity. 2014 Aug 21;41(2):181-90. doi: 10.1016/j.immuni.2014.07.007.
9
Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.
J Immunol. 2014 Jun 15;192(12):6071-82. doi: 10.4049/jimmunol.1303209. Epub 2014 May 9.
10
Theories and quantification of thymic selection.
Front Immunol. 2014 Feb 4;5:13. doi: 10.3389/fimmu.2014.00013. eCollection 2014.

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High determinant density may explain the phenomenon of alloreactivity.
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Not just any T cell receptor will do.
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Positive and negative selection of T cells.
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T cells down-modulate peptide-MHC complexes on APCs in vivo.
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A novel family of retroviral vectors for the rapid production of complex stable cell lines.
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Major histocompatibility complex proteins and TCRs: do they really go together like a horse and carriage?
J Immunol. 2001 Jul 15;167(2):617-21. doi: 10.4049/jimmunol.167.2.617.
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Immunological adjuvants promote activated T cell survival via induction of Bcl-3.
Nat Immunol. 2001 May;2(5):397-402. doi: 10.1038/87692.
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Crystal structure of a T cell receptor bound to an allogeneic MHC molecule.
Nat Immunol. 2000 Oct;1(4):291-7. doi: 10.1038/79728.
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Population biology of lymphocytes: the flight for survival.
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