DNA复制的起始：来自病毒起始蛋白的经验教训。

Initiation of DNA replication: lessons from viral initiator proteins.

作者信息

Stenlund Arne

机构信息

Cold Spring Harbor Laboratory, P.O. Box 100, 1 Bungtown Rd, Cold Spring Harbor, New York 11724, USA.

出版信息

Nat Rev Mol Cell Biol. 2003 Oct;4(10):777-85. doi: 10.1038/nrm1226.

DOI:10.1038/nrm1226

PMID:14504622

Abstract

Initiator proteins are key components of the DNA replication machinery that determine where initiation will occur. In the past few years, due to a greatly improved understanding of what viral initiators look like and how they function, we can now identify the basic tasks that are required of initiators, as well as begin to comprehend what activities are required to perform these tasks. The improved knowledge of the viral initiators also demonstrates an unexpected level of conservation between different viral initiators, which might extend also to their cellular counterparts.

摘要

引发蛋白是DNA复制机制的关键组成部分，它们决定了起始发生的位置。在过去几年里，由于对病毒引发蛋白的外观及其功能有了极大的了解，我们现在能够确定引发蛋白所需执行的基本任务，并且开始理解执行这些任务需要哪些活性。对病毒引发蛋白了解的加深也表明，不同病毒引发蛋白之间存在着意想不到的保守程度，这一点可能也适用于它们的细胞对应物。