Lee H-J, Chang C
Institute of Biotechnology and Department of Life Science, National Dong Hwa University, 974, Hualien, Taiwan.
Cell Mol Life Sci. 2003 Aug;60(8):1613-22. doi: 10.1007/s00018-003-2309-3.
Androgens, principally testosterone and 5 alpha-dihydrotestosterone, play critical roles in the development and growth of the male reproductive and nonreproductive systems. Their biological actions are mediated by the androgen receptor (AR), a ligand-dependent transcription factor, belonging to the nuclear receptor superfamily. These androgen-AR complexes interact with various factors (e.g. coactivators or corepressors) to modulate transcription of androgen target genes via specific DNA sequences. Many lines of evidence have also correlated AR with several mammalian disorders. Finally, recent advances in molecular biology have significantly impacted our knowledge of the role of AR in mammals. The aim of this review is to present recent emerging aspects of AR action.
雄激素，主要是睾酮和5α-二氢睾酮，在男性生殖系统和非生殖系统的发育与生长中发挥着关键作用。它们的生物学作用是由雄激素受体（AR）介导的，AR是一种配体依赖性转录因子，属于核受体超家族。这些雄激素-AR复合物与多种因子（如共激活因子或共抑制因子）相互作用，通过特定的DNA序列调节雄激素靶基因的转录。许多证据也将AR与多种哺乳动物疾病联系起来。最后，分子生物学的最新进展显著影响了我们对AR在哺乳动物中作用的认识。本综述的目的是介绍AR作用的最新新进展。
