Prosnitz E H, Zambraski E J, DiBona G F
Am J Physiol. 1977 Feb;232(2):F167-72. doi: 10.1152/ajprenal.1977.232.2.F167.
Bilateral carotid artery occlusion results in an increase in mean arterial pressure, an increase in renal sympathetic nerve activity, and a redistribution of renal blood flow from inner to outer cortex. To elucidate the mechanism of the renal blood flow redistribution, carotid artery occlusion was performed in anesthetized dogs with the left kidney either having renal perfusion pressure maintained constant (aortic constriction) or having alpha-adrenergic receptor blockade (phenoxybenzamine); the right kidney of the same dog served to document the normal response. When renal perfusion pressure was maintained constant, renal blood flow distribution (microspheres) was unchanged by carotid artery occlusion. In the presence of renal alpha-adrenergic receptor blockade, carotid artery occlusion elicited the usual redistribution of renal blood flow from inner to outer cortex. The redistribution of renal blood flow observed after carotid artery occlusion is mediated by the increase in renal perfusion pressure rather than the increase in renal sympathetic nerve activity.
双侧颈动脉闭塞会导致平均动脉压升高、肾交感神经活动增加以及肾血流从肾皮质内层向外层重新分布。为了阐明肾血流重新分布的机制，在麻醉犬身上进行颈动脉闭塞实验，实验中左肾要么保持肾灌注压恒定（主动脉缩窄），要么进行α-肾上腺素能受体阻断（酚苄明）；同一只犬的右肾用于记录正常反应。当肾灌注压保持恒定时，颈动脉闭塞并未改变肾血流分布（微球法）。在存在肾α-肾上腺素能受体阻断的情况下，颈动脉闭塞引发了肾血流从肾皮质内层向外层的典型重新分布。颈动脉闭塞后观察到的肾血流重新分布是由肾灌注压升高介导的，而非肾交感神经活动增加。
