血管嘌呤能神经释放ATP的机制。

Mechanisms of release of ATP from vascular purinergic nerves.

Chiba S, Yang X-P

Department of Pharmacology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.

Auton Autacoid Pharmacol. 2003 Apr;23(2):95-104. doi: 10.1046/j.1474-8673.2003.00283.x.

Abstract

The vasoconstrictor response to periarterial nerve electrical stimulation (PNS) and neurotransmission by ATP are discussed and illustrated, using canine isolated and perfused splenic arterial preparations. 2. The conditions for appearance of dominant purinergic constrictor response to PNS are discussed. 3. Modulation of the purinergic vasoconstrictor responses to PNS by several kinds of presynaptic receptor agonists and antagonists is reviewed. 4. Influences of purinergic responses to PNS by guanethidine, reserpine, tetrodotoxin (TTX) or omega-conotoxin GVIA (omegaCTX) are also reviewed. 5. Effects of imipramine and removal of the endothelium are discussed. 6. Evidence is presented for selective inhibition of purinergic responses to PNS by an adequate cold storage of the vessel. 7. The roles of ATP released by PNS in isolated canine splenic arteries are proposed.

摘要

使用犬离体灌注脾动脉标本，讨论并阐述了对动脉周围神经电刺激（PNS）的血管收缩反应以及ATP介导的神经传递。2. 讨论了对PNS出现主要嘌呤能收缩反应的条件。3. 综述了几种突触前受体激动剂和拮抗剂对PNS嘌呤能血管收缩反应的调节作用。4. 还综述了胍乙啶、利血平、河豚毒素（TTX）或ω-芋螺毒素GVIA（ωCTX）对PNS嘌呤能反应的影响。5. 讨论了丙咪嗪和去除内皮细胞后的作用。6. 提出了通过对血管进行适当冷藏选择性抑制对PNS嘌呤能反应的证据。7. 提出了PNS释放的ATP在离体犬脾动脉中的作用。