晚期促纤维增生性小圆细胞瘤成年患者高剂量化疗及自体外周血干细胞移植的前瞻性研究。
Prospective study of high-dose chemotherapy and autologous peripheral stem cell transplantation in adult patients with advanced desmoplastic small round-cell tumour.
作者信息
Bertuzzi A, Castagna L, Quagliuolo V, Ginanni V, Compasso S, Magagnoli M, Balzarotti M, Nozza A, Siracusano L, Timofeeva I, Sarina B, Parra H Soto, Santoro A
机构信息
Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, Rozzano, Milan 20089, Italy.
出版信息
Br J Cancer. 2003 Oct 6;89(7):1159-61. doi: 10.1038/sj.bjc.6601304.
A total of 10 desmoplastic small round-cell tumour patients were treated by high-dose chemotherapy with stem cell support. After high-dose chemotherapy, no complete response conversion was obtained and EWS-WT1 fusion transcript detection was positive in the peripheral blood during follow-up in all patients. High-dose chemotherapy did not seem to change the results in desmoplastic small round-cell tumour.
共有10例促结缔组织增生性小圆细胞肿瘤患者接受了大剂量化疗并辅以干细胞支持治疗。大剂量化疗后，未出现完全缓解转化，且在所有患者随访期间外周血中EWS-WT1融合转录本检测均呈阳性。大剂量化疗似乎并未改变促结缔组织增生性小圆细胞肿瘤的治疗结果。
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