[谷胱甘肽S-转移酶P1编码基因多态性与慢性阻塞性肺疾病的关联]

[Association between polymorphisms in the gene coding for glutathione S-transferase P1 and chronic obstructive pulmonary disease].

作者信息

Xiao Dan, Wang Chen, Du Min-jie, Pang Bao-sen, Zhang Hong-yu, Xiao Bai, Liu Jing-zhong, Weng Xin-zhi, Su Li, Christiani David C

机构信息

Beijing Chaoyang Hospital-Beijing Institute of Respiratory Medicine, Capital University of Medical Science, Beijing 100020, China.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2003 Sep;26(9):555-8.

PMID:14521761

Abstract

OBJECTIVE

To investigate the association between polymorphisms in the gene coding for glutathione S-transferase P1 (GSTP1) and susceptibility to chronic obstructive pulmonary disease (COPD) in a Chinese population.

METHODS

This was a pilot study of the molecular epidemiology in patients with COPD. The research design was a case-control study. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to genotype GSTP1 polymorphisms in exon 5 in 100 COPD patients and 100 age and sex matched healthy controls. Logistic regression analysis method was used to calculate the odds ratio (OR) and the 95% confidence interval (CI).

RESULT

There was no significant difference in GSTP1 polymorphisms adjusted by age, sex, body mass index and smoking between COPD patients and controls.

CONCLUSION

The gene polymorphism for GSTP1 was not associated with susceptibility to COPD in the Chinese population.

摘要

目的

探讨中国人群中谷胱甘肽S-转移酶P1（GSTP1）编码基因多态性与慢性阻塞性肺疾病（COPD）易感性之间的关联。

方法

这是一项针对COPD患者的分子流行病学初步研究。研究设计为病例对照研究。对100例COPD患者和100例年龄及性别匹配的健康对照者进行聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）分析，以确定GSTP1基因第5外显子的多态性基因型。采用逻辑回归分析方法计算比值比（OR）和95%置信区间（CI）。