神经科学。中枢神经系统的坚固守护者。
Neuroscience. Stout guards of the central nervous system.
作者信息
Mechoulam R, Lichtman A H
机构信息
Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Jerusalem 91120, Israel.
出版信息
Science. 2003 Oct 3;302(5642):65-7. doi: 10.1126/science.1091256.
PMID:14526067
Abstract
Endocannabinoids have paradoxical effects on the mammalian nervous system: Sometimes they block neuronal excitability and other times they augment it. In their Perspective, Mechoulam and Lichtman discuss new work (Marsicano et al.) showing that activation of the cannabinoid receptor CB1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy.
摘要
内源性大麻素对哺乳动物神经系统具有矛盾的作用
有时它们会阻断神经元兴奋性，而有时又会增强这种兴奋性。在他们的《观点》文章中，梅丘拉姆和利希特曼讨论了一项新研究（马尔西卡诺等人的研究），该研究表明内源性大麻素花生四烯乙醇胺激活大麻素受体CB1可在 kainic 酸诱导的癫痫小鼠模型中预防兴奋性毒性损伤。
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