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在巨人的帮助下。

With the help of giants.

作者信息

Fridovich Irwin

机构信息

Department of Biochemistry Duke University Medical Center Box 3711 Durham North Carolina 27710, USA.

出版信息

Annu Rev Biochem. 2003;72:1-18. doi: 10.1146/annurev.biochem.72.081902.140918.

Abstract

A childhood fascination with animals, plants, and insects was aided and abetted by many giants, beginning with my parents. The Bronx High School of Science and the City College of New York (CCNY) made a solid and priceless grounding in chemistry and biology available free of charge. Abe Mazur at CCNY revealed the wonders of biochemistry and illustrated that it was possible to pursue these wonders while being paid to do so. He also directed me to Duke University Medical School for PhD work under the tutelage of Phil Handler. With the exception of a sabbatical year at Harvard with Frank Westheimer, my entire career has been spent at Duke serving under three fine and supportive chairmen: Handler, Hill, and Raetz. The premier discoveries to emanate from my laboratory have been the sulfite oxidase, the several superoxide dismutases, the manganese catalase, and the catalase/peroxidase. Many other topics piqued my interest and resulted in ~ 400 publications. Herein I have recounted some of the circumstances surrounding that work and named a few of the people involved. The first 20 years I worked happily at the bench and the next 35 years just as happily facilitating the work of younger people. It has been so rewarding that I wish for nothing more than to be allowed to keep at it.

摘要

从孩提时代起,我就对动物、植物和昆虫充满了好奇,在许多杰出人士的帮助和支持下,这份好奇得以延续,其中首先要感谢我的父母。布朗克斯科学高中和纽约城市学院(CCNY)为我提供了扎实而无比珍贵的免费化学和生物学基础。纽约城市学院的阿贝·马祖尔向我揭示了生物化学的奇妙之处,并表明在从事这些奇妙研究的同时还能获得报酬。他还指导我前往杜克大学医学院,在菲尔·汉德勒的指导下攻读博士学位。除了在哈佛与弗兰克·韦斯特海默度过的一年休假外,我的整个职业生涯都在杜克大学度过,在三位优秀且支持我的系主任手下工作:汉德勒、希尔和雷茨。我实验室取得的首要发现包括亚硫酸盐氧化酶、几种超氧化物歧化酶、锰过氧化氢酶以及过氧化氢酶/过氧化物酶。许多其他课题也激发了我的兴趣,并促成了约400篇论文的发表。在此,我讲述了围绕这项工作的一些情况,并提到了一些相关人员。最初的20年我在实验台前快乐地工作,接下来的35年我同样快乐地助力年轻人开展工作。这份工作收获颇丰,我只希望能继续下去。

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