在接受腹腔镜胆囊切除术的患者中使用氟哌利多进行预防性止吐治疗。
Prophylactic antiemetic therapy with droperidol in patients undergoing laparoscopic cholecystectomy.
作者信息
Fujii Y, Tanaka H, Toyooka H
机构信息
Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, 2-1-1, Amakubo, Tsukuba City, Ibaraki 305, Japan.
出版信息
J Anesth. 1999;13(3):140-3. doi: 10.1007/s005400050045.
PURPOSE
The incidence of postoperative nausea and vomiting (PONV) following laparoscopic cholecystectomy (LC) is relatively high when no prophylactic antiemetic is given. We have studied the efficacy of a commonly used and well-established antiemetic, droperidol, for the prevention of PONV in patients undergoing LC.
METHODS
In a randomized, double-blind, placebo-controlled study, 60 patients received placebo (saline) or droperidol 50 microg.kg(-1) (maximum dose, 2.5 mg) intravenously immediately before the induction of anesthesia (n = 30 of each). A standard general anesthetic technique was employed throughout.
RESULTS
A complete response, defined as no PONV and no need for another rescue antiemetic medication during the first 24 h after anesthesia, was 57% and 83% in patients who had received placebo and droperidol 50 microg.kg(-1), respectively ( P < 0.05). No clinically serious adverse events were observed in any of the groups.
CONCLUSION
Prophylactic antiemetic therapy with droperidol 50 microg.kg(-1) (maximum dose, 2.5 mg) is highly effective for preventing PONV after LC.
目的
在未给予预防性止吐药的情况下，腹腔镜胆囊切除术（LC）后恶心呕吐（PONV）的发生率相对较高。我们研究了一种常用且成熟的止吐药氟哌利多预防LC患者PONV的疗效。
方法
在一项随机、双盲、安慰剂对照研究中，60例患者在麻醉诱导前即刻静脉注射安慰剂（生理盐水）或50μg·kg⁻¹氟哌利多（最大剂量2.5mg）（每组n = 30）。全程采用标准全身麻醉技术。
结果
麻醉后最初24小时内，定义为无PONV且无需使用其他抢救性止吐药的完全缓解率，接受安慰剂和50μg·kg⁻¹氟哌利多的患者分别为57%和83%（P < 0.05）。所有组均未观察到临床严重不良事件。
结论
50μg·kg⁻¹（最大剂量2.5mg）氟哌利多预防性止吐治疗对预防LC术后PONV非常有效。
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