Meyer Pamela A, Pivetz Timothy, Dignam Timothy A, Homa David M, Schoonover Jaime, Brody Debra
Division of Emergency and Environmental Health Services, National Center for Environmental Health, CDC, USA.
MMWR Surveill Summ. 2003 Sep 12;52(10):1-21.
PROBLEM/CONDITION: Lead is neurotoxic and particularly harmful to the developing nervous systems of fetuses and young children. Extremely high blood lead levels (BLLs) (i.e.,> or =70 microg/dL) can cause severe neurologic problems (e.g., seizure, coma, and death). However, no threshold has been determined regarding lead's harmful effects on children's learning and behavior. In 1990, the U.S. Department of Health and Human Services established a national goal to eliminate BLLs >25 microg/dL by 2000; a new goal targets elimination of BLLs > or =10 microg/dL in children aged <6 years by 2010.
Information regarding children's BLLs comes from 1) National Health and Nutrition Examination Surveys (NHANES) conducted during 1976-1980, 1988-1991, 1991-1994, and 1999-2000; and 2) state child blood lead surveillance data for test results collected during 1997-2001.
CDC tracks children's BLLs in the United States by using both NHANES and state and local surveillance data. NHANES reports data regarding children aged 1-5 years; state and local surveillance systems report data regarding children aged <72 months. Because lead exposure in children varies among populations and communities, both surveys are needed to determine the burden of elevated BLLs among young children throughout the United States. NHANES uses highly standardized data-collection procedures and probability samples to gather information regarding the health and nutritional status of the civilian, noninstitutionalized U.S. population. State and local childhood lead surveillance systems are based on reports of blood lead tests from laboratories. State and local programs submit data to CDC annually. In this report, confirmed elevated BLLs are defined as one venous blood specimen > or =10 microg/dL or two capillary blood specimens > or =10 microg/dL drawn within 12 weeks of each other.
The NHANES 1999-2000 survey estimated that 434,000 children (95% confidence interval = 189,000-846,000) or 2.2% of children aged 1-5 years had BLLs > or =10 microg/dL. For 2001, a total of 44 states, the District of Columbia (DC), and New York City (NYC) submitted child blood lead surveillance data to CDC. These jurisdictions represent 95% of the U.S. population of children aged <72 months and 97% of the nation's pre-1950 housing. The number of children tested and reported to CDC increased from 1,703,356 in 1997 (37 states, DC, and NYC reporting), to 2,422,298 in 2001 (44 states, DC, and NYC reporting). During that time, the number of children reported with confirmed elevated BLLs > or =10 microg/dL steadily decreased from 130,512 in 1997 to 74,887 in 2001. In 2000, the year targeted for national elimination of BLLs >25 microg/dL, a total of 8,723 children had BLLs > or =25 microg/dL.
Both national surveys and state surveillance data indicate children's BLLs continue to decline throughout the United States. However, thousands of children continue to be identified with elevated BLLs. The 2000 goal of eliminating BLLs >25 microg/dL was not met. Attaining the 2010 goal of eliminating BLLs > or =10 microg/dL will require intensified efforts to target areas at highest risk, evaluate preventive measures, and improve the quality of surveillance data.
States will continue to use surveillance data to 1) promote legislation supporting lead poisoning prevention activities, 2) obtain funding, 3) identify risk groups, 4) target and evaluate prevention activities, and 5) monitor and describe progress toward elimination of BLLs > or =10 microg/dL. CDC will work with state and local programs to improve tracking systems and the collection, timeliness, and quality of surveillance data.
问题/状况:铅具有神经毒性,对胎儿和幼儿正在发育的神经系统尤其有害。极高的血铅水平(BLLs)(即≥70微克/分升)可导致严重的神经问题(如癫痫发作、昏迷和死亡)。然而,关于铅对儿童学习和行为的有害影响,尚未确定阈值。1990年,美国卫生与公众服务部设定了一个全国目标,到2000年消除血铅水平>25微克/分升的情况;一个新目标是到2010年消除6岁以下儿童血铅水平≥10微克/分升的情况。
关于儿童血铅水平的信息来自:1)1976 - 1980年、1988 - 1991年、1991 - 1994年以及1999 - 2000年期间开展的国家健康与营养检查调查(NHANES);2)1997 - 2001年期间收集的儿童血铅监测数据。
美国疾病控制与预防中心(CDC)通过使用NHANES以及州和地方监测数据来追踪美国儿童的血铅水平。NHANES报告1 - 5岁儿童的数据;州和地方监测系统报告72个月以下儿童的数据。由于不同人群和社区中儿童的铅暴露情况存在差异,所以需要这两项调查来确定全美国幼儿血铅水平升高的负担情况。NHANES采用高度标准化的数据收集程序和概率样本,以收集有关美国平民、非机构化人口的健康和营养状况的信息。州和地方儿童铅监测系统基于实验室血铅检测报告。州和地方项目每年向CDC提交数据。在本报告中,确诊血铅水平升高定义为一份静脉血样本≥10微克/分升或两份毛细血管血样本在彼此相隔12周内采集且均≥10微克/分升。
1999 - 2000年的NHANES调查估计,434,000名儿童(95%置信区间 = 189,000 - 846,000),即1 - 5岁儿童中的2.2%,血铅水平≥10微克/分升。2001年,共有44个州、哥伦比亚特区(DC)和纽约市(NYC)向CDC提交了儿童血铅监测数据。这些辖区代表了美国72个月以下儿童人口的95%以及该国1950年前住房的97%。向CDC检测并报告的儿童数量从1997年的1,703,356名(37个州、DC和NYC报告)增加到2001年的2,422,298名(44个州、DC和NYC报告)。在此期间,报告的确诊血铅水平≥10微克/分升的儿童数量从1997年的130,512名稳步下降到2001年的74,887名。在2000年,即全国目标消除血铅水平>25微克/分升的那一年,共有8,723名儿童血铅水平≥25微克/分升。
全国性调查和州监测数据均表明,全美国儿童的血铅水平持续下降。然而,仍有成千上万的儿童被确定血铅水平升高。2000年消除血铅水平>25微克/分升的目标未实现。要实现2010年消除血铅水平≥10微克/分升的目标,需要加大力度针对风险最高的地区,评估预防措施,并提高监测数据的质量。
各州将继续利用监测数据来:1)推动支持预防铅中毒活动的立法,2)获取资金,3)识别风险群体,4)针对并评估预防活动,以及5)监测和描述在消除血铅水平≥10微克/分升方面的进展。CDC将与州和地方项目合作,改进追踪系统以及监测数据的收集、及时性和质量。