α-生育酚对大鼠肝脏中异生物质代谢酶活性的剂量依赖性效应。

Dose-dependent effect of alpha-tocopherol on activity of xenobiotic metabolizing enzymes in rat liver.

作者信息

Sidorova Yu A, Ivanova E V, Grishanova A Yu, Lyakhovich V V

机构信息

Laboratory of Foreign Compounds Biochemistry, Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.

出版信息

Bull Exp Biol Med. 2003 Jul;136(1):38-41. doi: 10.1023/a:1026080611490.

DOI:10.1023/a:1026080611490

PMID:14534606

Abstract

Oral treatment with alpha-tocopherol for 4 days dose-dependently increased the content of cytochrome P450 (CYP), catalytic activities of CYP1A1, CYP1A2, CYP2B1, CYP2C, and activity of NADPH-cytochrome-P450 reductase in the liver of male rats, but did not change activity of glutathione S-transferase. These results suggest that alpha-tocopherol induced the enzymes of phase I of xenobiotic metabolism, including CYP1 and CYP2 families involved in the metabolism of drugs and procarcinogenes.

摘要

用α-生育酚对雄性大鼠进行4天的口服治疗，可使细胞色素P450（CYP）含量、CYP1A1、CYP1A2、CYP2B1、CYP2C的催化活性以及肝脏中NADPH-细胞色素-P450还原酶的活性呈剂量依赖性增加，但谷胱甘肽S-转移酶的活性未发生变化。这些结果表明，α-生育酚诱导了外源性物质代谢I相的酶，包括参与药物和前致癌物代谢的CYP1和CYP2家族。