Otte Arie P, Kwaks Ted H J
Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands.
Curr Opin Genet Dev. 2003 Oct;13(5):448-54. doi: 10.1016/s0959-437x(03)00108-4.
Polycomb group (PcG) proteins play important roles in maintaining the repressed transcriptional state of genes. PcG proteins operate as part of Polycomb repressive complexes (PRCs). 'Core' PRCs have been purified that contain only a limited number of PcG proteins. In addition, many gene regulatory proteins have been identified to interact with PcG proteins. However, it remains subject to discussion whether these interactions are transient or whether the regulatory proteins are real components of PRCs. It has also become clear that the compositions of 'core' PRCs differ amongst cell types and that extensive changes in compositions occur during the embryonic development of cells. Because of these dynamic changes, we argue that speaking of a definitive core PRC can be misleading.
多梳蛋白家族（PcG）在维持基因的转录抑制状态中发挥着重要作用。PcG蛋白作为多梳抑制复合物（PRCs）的一部分发挥作用。已纯化出仅包含有限数量PcG蛋白的“核心”PRCs。此外，已鉴定出许多基因调控蛋白与PcG蛋白相互作用。然而，这些相互作用是短暂的，还是调控蛋白是PRCs的真正组成部分，仍有待讨论。同样清楚的是，“核心”PRCs的组成在不同细胞类型中存在差异，并且在细胞的胚胎发育过程中会发生广泛的组成变化。由于这些动态变化，我们认为提及确定的核心PRC可能会产生误导。
