树突状细胞和B细胞中CpG DNA的差异信号传导：不仅仅是Toll样受体9。
Differential signaling by CpG DNA in DCs and B cells: not just TLR9.
作者信息
Verthelyi Daniela, Zeuner Rainald A
机构信息
Division of Therapeutic Proteins, Center for Biologics Research and Evaluation, Food and Drug Administration, Bldg 29A Rm 3B19, 8800 Rockville Pike, Bethesda, MD 20892, USA.
出版信息
Trends Immunol. 2003 Oct;24(10):519-22. doi: 10.1016/s1471-4906(03)00243-6.
CpG-containing oligodeoxynucleotides (CpG ODNs) act on Toll-like receptor 9 (TLR9) that is expressed on B cells and plasmacytoid dendritic cells (pDCs) to stimulate the innate immune system, however, different types of CpG ODNs induce distinct responses. Recent papers suggest some CpG ODNs could require a second receptor or cofactor to signal. The different signaling complexes assembled might impact on the affinity with which CpG ODNs signal to TLR9 or activate additional pathways that lead to distinct immune responses.
含CpG的寡脱氧核苷酸（CpG ODNs）作用于B细胞和浆细胞样树突状细胞（pDCs）上表达的Toll样受体9（TLR9），以刺激先天免疫系统，然而，不同类型的CpG ODNs会诱导不同的反应。最近的论文表明，一些CpG ODNs可能需要第二种受体或辅助因子来发出信号。组装的不同信号复合物可能会影响CpG ODNs向TLR9发出信号的亲和力，或激活导致不同免疫反应的其他途径。
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