Cademartiri Filippo, Nieman Koen, Mollet Nico, Flohr Thomas G, Alfieri Ottavio, de Feyter Pim J, Krestin Gabriel P
Dipartimento di Radiologia, Erasmus Medical Center, Dr. Molenwaterplein, 40 3015 GD Rotterdam, The Netherlands.
Ital Heart J Suppl. 2003 Jul;4(7):587-93.
The gold standard for direct diagnostic imaging of coronary arteries is still conventional X-ray coronary angiography, even though for several other applications, noninvasive techniques substituted invasive ones. In the last 10 years several techniques (magnetic resonance, electron beam tomography, spiral computed tomography) attempted to emerge as noninvasive modality for the study of coronary arteries. The introduction of multislice computed tomography (MSCT) with retrospectively gated ECG reconstructions has substantially modified the coronary imaging scenario. In fact, the results have been promising since the beginning with 4-row MSCT. Currently the results reported with 16-row MSCT allow to question which role can the noninvasive coronary angiography play in clinical settings. With a scan of < 20 s after intravenous administration of iodinated contrast material it is possible to obtain information similar to conventional coronary angiography. Moreover, together with vascular patency, also atherosclerotic plaques are well visualized and characterized (type: calcified, soft, mixed). Ongoing studies are validating MSCT in the assessment of plaque vulnerability. The same technique allows to evaluate left ventricular function and myocardial wall motion impairment. Still with a few major limitations related to the heart rate, MSCT will broaden the noninvasive capability of evaluating coronary arteries in patients where conventional coronary angiography is exceeding the actual clinical question or considered as premature.
冠状动脉直接诊断成像的金标准仍然是传统的X射线冠状动脉造影,尽管在其他一些应用中,非侵入性技术已取代了侵入性技术。在过去十年中,有几种技术(磁共振、电子束断层扫描、螺旋计算机断层扫描)试图成为研究冠状动脉的非侵入性方法。多层螺旋计算机断层扫描(MSCT)结合回顾性门控心电图重建技术的引入,极大地改变了冠状动脉成像的局面。事实上,从4排MSCT开始,结果就很有前景。目前,16排MSCT报告的结果让人质疑非侵入性冠状动脉造影在临床环境中能发挥何种作用。静脉注射碘化造影剂后,在不到20秒的扫描时间内,就有可能获得与传统冠状动脉造影相似的信息。此外,除了血管通畅情况外,动脉粥样硬化斑块也能很好地显示并进行特征描述(类型:钙化、柔软、混合)。正在进行的研究正在验证MSCT在评估斑块易损性方面的作用。同样的技术还可以评估左心室功能和心肌壁运动障碍。尽管仍存在一些与心率相关的主要局限性,但MSCT将扩大在传统冠状动脉造影超出实际临床问题或被认为为时过早的患者中评估冠状动脉的非侵入性能力。