Rao C R, Jain K, Bhatia K, Laksmaiah K C, Shankar S K
Kidwai Memorial Institute of Oncology, Department of Neuropathology, NIMHANS, Bangalore 560-029, India.
Neurol India. 2003 Jun;51(2):237-40.
The incidence of primary central nervous system lymphoma (PCNSL), previously a rare tumor, has increased significantly over the past few decades, partly due to the AIDS epidemic but also in immunocompetent individuals. Studies from Western countries have shown a consistent association of tumors occurring in immunocompromised individuals with the Epstein-Barr virus (EBV) suggesting an important role for the virus in the pathogenesis of these tumors, but an infrequent association of the virus with PCNSL in the immunocompetent host has also been noted. We studied 11 patients with PCNSL who had no evidence of an immunocompromised state. All the tumors were aggressive B cell lymphomas. EBV association was studied using EBER in-situ hybridization. 10 out of the 11 tumors were negative for EBV, indicating that tumors in immunocompetent individuals in developing countries are also infrequently EBV associated and that a different pathogenetic mechanism is operative in the evolution of these tumors.
原发性中枢神经系统淋巴瘤（PCNSL）以往是一种罕见肿瘤，在过去几十年中其发病率显著上升，部分原因是艾滋病流行，但在免疫功能正常的个体中也有增加。西方国家的研究表明，免疫功能低下个体中发生的肿瘤与爱泼斯坦-巴尔病毒（EBV）存在持续关联，提示该病毒在这些肿瘤的发病机制中起重要作用，但也有人指出该病毒在免疫功能正常宿主中与PCNSL的关联并不常见。我们研究了11例无免疫功能低下状态证据的PCNSL患者。所有肿瘤均为侵袭性B细胞淋巴瘤。使用EBER原位杂交研究EBV关联情况。11例肿瘤中有10例EBV呈阴性，表明发展中国家免疫功能正常个体中的肿瘤也很少与EBV相关，且这些肿瘤的发生存在不同的发病机制。
